Внутривенно капельно, на 0,5 % растворе декстрозы или 0,9 % растворе хлорида натрия в концентрации 0,1-0,2 %.

Внутриполостно: по 10-50 мл 1 % раствора через шприц, катетер или дренажную трубку.

Высшая суточная доза: 600 мг.

Высшая разовая доза: 300 мг.

","

Центральная и периферическая нервная система: головокружение, головная боль, галлюцинации.

Пищеварительная система: гастралгия, рвота, диарея.

Костно-мышечная система: тетания (судороги икроножных мышц).

Дерматологические реакции: сыпь, кандидоз.

Озноб, лихорадка, аллергические реакции.

","

Надпочечниковая и печеночная недостаточность, индивидуальная непереносимость, детский возраст до 18 лет.

","specialInstructions","

Применение препарата возможно только в условиях стационара под контролем врача.

","interactions","

Клинически значимых взаимодействий не описано.

","overdose","

Острая надпочечниковая недостаточность, дистрофия.

Лечение симптоматическое.

","actionMechanism","pharmacodynamic","

Синтетическое антибактериальное средство, производное хиноксалина. Активирует процессы перекисного окисления, которые приводят к нарушению биосинтеза ДНК и глубоким структурным изменениям в цитоплазме микробных клеток.

Оказывает бактерицидное действие в отношении палочки палочки Фридлендера, Proteus vulgaris, Pseudomonas aeruginosa, Escherichia coli, Salmonella spp., Shigella dysenteria, Shigella boydii, Shigella flexneri, Shigella sonnei, Staphylococcus spp., Streptococcus spp., анаэробов Clostridium perfringens.

","pharmacokinetic","

После внутривенного введения максимальная концентрация в плазме крови достигается через 1-2 часа.

Проникает через гематоэнцефалический и плацентарный барьер, экскретируется с грудным молоком. Метаболизм в печени.

Период полувыведения составляет 6 часов. Элиминация почками.

","pregnancy","

Рекомендации по FDA - категория D. Противопоказан при беременности и в период лактации.

","fertility","precautions","

Почечная недостаточность.

","indications","

Применяется для лечения цистита, пиелита, холангита, холецистита, сепсиса, абсцесса легкого, эмпиемы легких.

","drivingInstructions","icd10",[199,211,217,223,230,236,242,248,254,260,266,272,278,284,290,296,302,308,314,320],{"_200":201,"_164":202,"_162":203,"_204":201,"_159":205,"_5":206,"_207":208,"_209":210},"drugGeotarID","A39","Meningococcal infection","Менингококковая инфекция","drugICD10CodeShort","QTM5","DrugICD10","code","I(A00-B99).A30-A49.A39","level","3",{"_200":212,"_164":213,"_162":214,"_204":212,"_159":215,"_5":206,"_207":216,"_209":210},"A40","Streptococcal sepsis","Стрептококковый сепсис","QTQw","I(A00-B99).A30-A49.A40",{"_200":218,"_164":219,"_162":220,"_204":218,"_159":221,"_5":206,"_207":222,"_209":210},"A41","Other sepsis","Другой сепсис","QTQx","I(A00-B99).A30-A49.A41",{"_200":224,"_164":225,"_162":226,"_204":224,"_159":227,"_5":206,"_207":228,"_209":229},"I83.2","Varicose veins of lower extremities with both ulcer and inflammation","Варикозное расширение вен нижних конечностей с язвой и воспалением","STgzLjI","IX(I00-I99).I80-I89.I83.2","4",{"_200":231,"_164":232,"_162":233,"_204":231,"_159":234,"_5":206,"_207":235,"_209":210},"G00","Bacterial meningitis, not elsewhere classified","Бактериальный менингит, не классифицированный в других рубриках","RzAw","VI(G00-G99).G00-G09.G00",{"_200":237,"_164":238,"_162":239,"_204":237,"_159":240,"_5":206,"_207":241,"_209":210},"J85","Abscess of lung and mediastinum","Абсцесс легкого и средостения","Sjg1","X(J00-J99).J85-J86.J85",{"_200":243,"_164":244,"_162":245,"_204":243,"_159":246,"_5":206,"_207":247,"_209":210},"J86","Pyothorax","Пиоторакс","Sjg2","X(J00-J99).J85-J86.J86",{"_200":249,"_164":250,"_162":251,"_204":249,"_159":252,"_5":206,"_207":253,"_209":210},"J90","Pleural effusion, not elsewhere classified","Плевральный выпот, не классифицированный в других рубриках","Sjkw","X(J00-J99).J90-J94.J90",{"_200":255,"_164":256,"_162":257,"_204":255,"_159":258,"_5":206,"_207":259,"_209":229},"K65.0","Acute peritonitis","Острый перитонит","SzY1LjA","XI(K00-K93).K65-K67.K65.0",{"_200":261,"_164":262,"_162":263,"_204":261,"_159":264,"_5":206,"_207":265,"_209":210},"K81","Cholecystitis","Холецистит","Szgx","XI(K00-K93).K80-K87.K81",{"_200":267,"_164":268,"_162":269,"_204":267,"_159":270,"_5":206,"_207":271,"_209":229},"K81.0","Acute cholecystitis","Острый холецистит","SzgxLjA","XI(K00-K93).K80-K87.K81.0",{"_200":273,"_164":274,"_162":275,"_204":273,"_159":276,"_5":206,"_207":277,"_209":229},"K83.0","Cholangitis","Холангит","SzgzLjA","XI(K00-K93).K80-K87.K83.0",{"_200":279,"_164":280,"_162":281,"_204":279,"_159":282,"_5":206,"_207":283,"_209":210},"L01","Impetigo","Импетиго","TDAx","XII(L00-L99).L00-L08.L01",{"_200":285,"_164":286,"_162":287,"_204":285,"_159":288,"_5":206,"_207":289,"_209":210},"L02","Cutaneous abscess, furuncle and carbuncle","Абсцесс кожи, фурункул и карбункул","TDAy","XII(L00-L99).L00-L08.L02",{"_200":291,"_164":292,"_162":293,"_204":291,"_159":294,"_5":206,"_207":295,"_209":210},"L03","Cellulitis","Флегмона","TDAz","XII(L00-L99).L00-L08.L03",{"_200":297,"_164":298,"_162":299,"_204":297,"_159":300,"_5":206,"_207":301,"_209":229},"M86","Osteomyelitis","Остеомиелит","TTg2","XIII(M00-M99).M80-M94.M86-M90.M86",{"_200":303,"_164":304,"_162":305,"_204":303,"_159":306,"_5":206,"_207":307,"_209":210},"N12","Tubulo-interstitial nephritis, not specified as acute or chronic","Тубулоинтерстициальный нефрит, не уточненный как острый или хронический","TjEy","XIV(N00-N99).N10-N16.N12",{"_200":309,"_164":310,"_162":311,"_204":309,"_159":312,"_5":206,"_207":313,"_209":210},"N30","Cystitis","Цистит","TjMw","XIV(N00-N99).N30-N39.N30",{"_200":315,"_164":316,"_162":317,"_204":315,"_159":318,"_5":206,"_207":319,"_209":210},"N61","Inflammatory disorders of breast","Воспалительные болезни молочной железы","TjYx","XIV(N00-N99).N60-N64.N61",{"_200":321,"_164":322,"_162":323,"_204":321,"_159":324,"_5":206,"_207":325,"_209":229},"T79.3","Post-traumatic wound infection, not elsewhere classified","Посттравматическая раневая инфекция, не классифицированная в других рубриках","VDc5LjM","XIX(S00-T98).T79-T79.T79.3","atc",[328],{"_200":329,"_164":330,"_162":331,"_159":332,"_5":333,"_207":332,"_209":229},"J.01.X.X","Other Antibacterials","Прочие антибактериальные препараты","J01XX","DrugATC","contraindicationsList","precautionsList","adverseEffectList",[],"pharmGroupList","12.7.3 Другие синтетические антибактериальные средства","substanceType","Непатентованное международное наименование","structure","[?] ","image",{"_40":346,"_347":10},"/images/substance-placeholder.jpg","isPlaceholder","esklp",{"_350":351,"_352":-5},"esklpList",[],"isInnVital","aggregatedEsklpGroups",[],"entityId","https://www.lsgeotar.ru/substances/hydroxymethylnicotinamidum-AARq/interactions","substanceInteractions",{"_42":359,"_365":126,"_366":367,"_368":369},{"_360":361,"_362":72,"_363":126,"_364":-5},"query","","pageSize","page","filters","total","countedSignificances",[],"interactionList",[],"pages/PagesLayout","actionData","errors"]

Гидроксиметилхиноксалиндиоксид (Hydroxymethylnicotinamidum)