[{"_1":2,"_346":-5,"_347":-5},"loaderData",{"_3":4,"_132":133,"_276":277,"_345":-5},"root",{"_5":6,"_97":98,"_117":118},"appConfig",{"_7":8,"_9":10,"_11":12,"_13":14,"_15":16,"_17":18,"_19":20,"_47":48,"_49":50,"_59":60,"_61":62},"lsEnabled",true,"salesEmail","sale@lsgeotar.ru","supportEmail","support@lsgeotar.ru","infoEmail","info@lsgeotar.ru","primaryPhoneNumber","8 (800) 234-13-74","secondaryPhoneNumber","+7 (985) 750-03-09","medBase",{"_21":22,"_23":-5,"_24":25,"_26":27,"_28":29,"_30":31,"_32":33,"_34":35,"_36":37,"_46":39},"baseUrl","https://medbase.ru","ssr","loginIframeUrl","https://medbase.ru/bind_external_user.html","userProfileUrl","https://medbase.ru/cur_user/general.html","aboutUrl","/pages/about.html","bookUrl","/book/{{id}}.html","readerUrl","/doc/{{id}}-0001/0001.html","selfDomain","https://www.lsgeotar.ru","payment",{"_38":39,"_40":41},"url","https://medbase.ru/pages/buy_acc.html","params",{"_42":43,"_44":45},"tab","LS-DDI","XFrom","lsgeotar","buySubscriptionUrl","geotarCifraUrl","https://cifra.geotar.ru","analytics",{"_51":52,"_55":56},"yandexMetrika",{"_53":54},"counterId","35376590","googleAnalytics",{"_57":58},"measurementId","G-FRG71EZEZG","isDevHost",false,"quotas",{"_63":64,"_86":87,"_91":92},"anonymous",{"_65":66,"_71":72},"limits",{"_67":68,"_69":70},"medication-check.input.max",2,"substance.interactions.max",3,"features",{"_73":60,"_74":60,"_75":60,"_76":60,"_77":60,"_78":8,"_79":60,"_80":8,"_81":60,"_82":60,"_83":60,"_84":60,"_85":60},"medication-check.results.export","substance.interactions.filter","substance.interactions.extended-interaction-info","entity.instructions.view","esklp.substance.info","meddra","meddra.substance.info","meddra.medication-check.adverse-effects","meddra.medication-check.adverse-effects.content","clinrecs","clinrecs.clinrec.medications","clinrecs.substance.clinrecs","clinrecs.medication-check","registered",{"_65":88,"_71":90},{"_67":89,"_69":89},5,{"_73":60,"_74":8,"_75":60,"_76":8,"_77":60,"_78":8,"_79":60,"_80":8,"_81":60,"_82":60,"_83":60,"_84":60,"_85":60},"pro",{"_65":93,"_71":96},{"_67":94,"_69":95},50,20000,{"_73":8,"_74":8,"_75":60,"_76":8,"_77":8,"_78":8,"_79":8,"_80":8,"_81":8,"_82":60,"_83":60,"_84":60,"_85":60},"userInfo",{"_99":60,"_100":-5,"_101":-5,"_102":63,"_103":63,"_104":105,"_61":106,"_109":110},"isAuthenticated","firstName","lastName","accessType","userName","roles",[],{"_65":107,"_71":108},{"_67":68,"_69":70},{"_73":60,"_74":60,"_75":60,"_76":60,"_77":60,"_78":8,"_79":60,"_80":8,"_81":60,"_82":60,"_83":60,"_84":60,"_85":60},"bffQuotas",{"_111":112,"_113":68,"_114":70,"_115":112,"_116":112},"instructions.view",0,"interactions.calculator.input.max","interactions.list.results.max","inn.dosages.view","interactions.calculator.report.download","userProfile",{"_119":120},"settings",{"_121":122,"_124":128,"_130":131},"layout",{"_123":60,"_124":125,"_126":127},"tablePinPrimaryColumn","contraindications","table","adverseEffects","soc",{"_129":60},"hidePregnancyAndAge","dontShowAgain",{},"substance",{"_134":135,"_274":139,"_38":275},"data",{"_136":137,"_138":139,"_140":141,"_142":143,"_144":145,"_146":147,"_148":-5,"_149":150,"_151":112,"_152":-7,"_153":154,"_126":155,"_124":156,"_157":158,"_159":160,"_161":162,"_163":-7,"_164":165,"_166":167,"_168":169,"_170":-7,"_171":172,"_173":174,"_175":-7,"_176":177,"_234":235,"_242":243,"_248":249,"_255":256,"_257":258,"_259":260,"_261":262,"_263":264,"_267":268,"_272":273},"itemClass","InnCard","id","ABic","type","DrugINN","name","Гидрокортизон + Хлоргексидин","internationalName","Hydrocortisonum+ Chlorhexidinum","geotarId","2350","drugBankId","docAttachments",[],"clinRecCount","description","application","

Наружно, крем наносится на пораженные участки кожи 2-4 раза в сутки.

","

Аллергические реакции, фотосенсибилизация. При длительном применении - угревая сыпь, стрии, атрофия кожи.

","

Вирусные инфекции и туберкулез кожи, сифилис, акне, грибковые и предраковые заболевания кожи, периоральный дерматит, индивидуальная непереносимость, детский возраст до 3-х лет.

","specialInstructions","

Во время лечения не рекомендуется проводить вакцинацию, принимать солнечные ванны и посещать солярий.

","interactions","

Клинически значимых взаимодействий не описано.

","overdose","

Случаи передозировки не описаны.

Лечение симптоматическое.

","actionMechanism","pharmacodynamic","

Комбинированный препарат для наружного применения.

Гидрокортизон

Путем торможения активности фосфолипазы А₂ и снижения высвобождения арахидоновой кислоты из фосфолипидов клеточных мембран уменьшает продукцию лейкотриенов и простагландинов. За счет этого подавляет развитие воспалительных проявлений: боли, отека, повышения температуры и покраснения в области воспаления. Тормозит экспрессию гена циклооксигеназы-2, что также приводит к угнетению синтеза простагландинов.

Редуцирует основное вещество соединительной ткани, ослабляя экссудативные и пролиферативные процессы в коже. Ингибирует клеточные кинины, обладающие протеолитической активностью. Препятствует доступу макрофагов и Т-сенсибилизированных лимфоцитов к очагам воспаления.

Оказывает противовоспалительное, противоотечное и противоаллергическое действие.

Хлоргексидин

Неспецифически связывается с фосфолипидами клеточной стенки бактерии, инактивирует АТФазу и дегидрогеназу, нарушает проницаемость мембраны для калия, аминокислот и нуклеотидов.

Активен в отношении грамположительных микроорганизмов: Escherichia coli, Selenomonas, Streptococcus salivarius, Streptococcus mutans, анаэробов и грибов рода Candida albicans, в меньшей степени - грамотрицательных микроорганизмов: Pseudomonas, Proteus, Streptococcus sanguis, Klebsiella spp., Veillonella species.

","pharmacokinetic","

Препарат для местного применения, системного действия на организм не оказывает.

","pregnancy","

Рекомендации по FDA - категория С. С осторожностью применяется во время беременности и лактации в тех случаях, когда предполагаемая польза превышает риск для плода и новорожденного.

","fertility","precautions","

Беременность и лактация, гиперчувствительность.

","indications","

Применяется для лечения пиодермии, атопического дерматита, экземы, инфекционного миозита. Используется при бурситах, абсцессах синовиальной сумки и сухожилий.

","drivingInstructions","icd10",[178,190,197,203,210,216,222,228],{"_179":180,"_144":181,"_142":182,"_183":180,"_138":184,"_140":185,"_186":187,"_188":189},"drugGeotarID","L00-L08","Infections of the skin and subcutaneous tissue","ИНФЕКЦИИ КОЖИ И ПОДКОЖНОЙ КЛЕТЧАТКИ","drugICD10CodeShort","TDAwLUwwOA","DrugICD10","code","XII(L00-L99).L00-L08","level","2",{"_179":191,"_144":192,"_142":193,"_183":191,"_138":194,"_140":185,"_186":195,"_188":196},"L30.3","Infective dermatitis","Инфекционный дерматит","TDMwLjM","XII(L00-L99).L20-L30.L30.3","4",{"_179":198,"_144":199,"_142":200,"_183":198,"_138":201,"_140":185,"_186":202,"_188":196},"L30.9","Dermatitis, unspecified","Дерматит неуточненный","TDMwLjk","XII(L00-L99).L20-L30.L30.9",{"_179":204,"_144":205,"_142":206,"_183":204,"_138":207,"_140":185,"_186":208,"_188":209},"M60.0","Infective myositis","Инфекционный миозит","TTYwLjA","XIII(M00-M99).M60-M79.M60-M63.M60.0","5",{"_179":211,"_144":212,"_142":213,"_183":211,"_138":214,"_140":185,"_186":215,"_188":209},"M65.0","Abscess of tendon sheath","Абсцесс оболочки сухожилия","TTY1LjA","XIII(M00-M99).M60-M79.M65-M68.M65.0",{"_179":217,"_144":218,"_142":219,"_183":217,"_138":220,"_140":185,"_186":221,"_188":209},"M65.1","Other infective (teno)synovitis","Другие инфекционные (тено)синовиты","TTY1LjE","XIII(M00-M99).M60-M79.M65-M68.M65.1",{"_179":223,"_144":224,"_142":225,"_183":223,"_138":226,"_140":185,"_186":227,"_188":209},"M71.0","Abscess of bursa","Абсцесс синовиальной сумки","TTcxLjA","XIII(M00-M99).M60-M79.M70-M79.M71.0",{"_179":229,"_144":230,"_142":231,"_183":229,"_138":232,"_140":185,"_186":233,"_188":209},"M71.1","Other infective bursitis","Другие инфекционные бурситы","TTcxLjE","XIII(M00-M99).M60-M79.M70-M79.M71.1","atc",[236],{"_179":237,"_144":238,"_142":239,"_138":240,"_140":241,"_186":240,"_188":209},"D.07.B.A.04","Hydrocortisone And Antiseptics","Гидрокортизон и антисептики","D07BA04","DrugATC","contraindicationsList",[244],{"_142":245,"_138":246,"_140":247,"_179":246},"Детский возраст до 3 лет","chld_3","DrugPatientStatus","precautionsList",[250,253],{"_142":251,"_138":252,"_140":247,"_179":252},"Кормление грудью","breast_feeding",{"_142":254,"_138":168,"_140":247,"_179":168},"Беременность","adverseEffectList",[],"pharmGroupList","

12.2 Антисептики и дезинфицирующие средства
4.6.1 Глюкокортикостероиды

","substanceType","Непатентованное международное наименование","structure","[?] ","image",{"_38":265,"_266":8},"/images/substance-placeholder.jpg","isPlaceholder","esklp",{"_269":270,"_271":-5},"esklpList",[],"isInnVital","aggregatedEsklpGroups",[],"entityId","https://www.lsgeotar.ru/substances/hydrocortisonum-chlorhexidinum-ABic/drugs","substanceDrugs",[278,296],{"_40":279,"_293":112,"_294":295},{"_280":281,"_282":283,"_284":112,"_285":286},"query","","pageSize",25,"page","filters",[287],{"_140":288,"_142":-5,"_289":290,"_291":292},"drugINNAtomic","values",[139],"operator","IN","total","items",[],{"_297":298,"_340":341},"facets",[299,304,308,312,316,320,324,328,332,336],{"_142":300,"_301":302,"_294":303},"Лекарственная форма","propertyId","drugDosageForm",[],{"_142":305,"_301":306,"_294":307},"Вид ТН","drugTNType",[],{"_142":309,"_301":310,"_294":311},"Нормативный список ТН","drugTNList",[],{"_142":313,"_301":314,"_294":315},"Способ применения","drugDosageType",[],{"_142":317,"_301":318,"_294":319},"Список наркотических средств и психотропных веществ","drugNarcoticList",[],{"_142":321,"_301":322,"_294":323},"Условия отпуска из аптек","drugDispensingCondition",[],{"_142":325,"_301":326,"_294":327},"Противопоказания","drugContraindicationStd",[],{"_142":329,"_301":330,"_294":331},"Применение с осторожностью","drugUseCautionStd",[],{"_142":333,"_301":334,"_294":335},"Статус регистрационного удостоверения в РФ","drugRegistrationStatus",[],{"_142":337,"_301":338,"_294":339},"Дата регистрации ТН","drugTNRegistrationDate",[],"searchParameters",{"_280":281,"_282":283,"_284":112,"_285":342},[343],{"_140":288,"_142":-5,"_289":344,"_291":292},[139],"pages/PagesLayout","actionData","errors"]

Гидрокортизон + Хлоргексидин (Hydrocortisonum+ Chlorhexidinum)