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Для приема внутрь (через рот), в виде клизм, аппликаций, орошений, введения в полости ран, вагины, матки, носа, пазух носа, а также в дренированные полости: абсцессов, брюшную, плевральную, мочевого пузыря, почечной лоханки.

Внутрь препарат принимают натощак за 0,5-1 час до приема пищи.

При лечении ангин, фарингитов, ларингитов препарат используют для полосканий полости рта и глотки 3 раза в день по 10-20 мл, курс лечения 7-10 дней.

При лечении бронхитов, пневмоний препарат принимают внутрь 3 раза в день по 10-20 мл, а также применяют в виде аэрозолей и ингаляций (без подогрева и использования ультразвука), курс лечения 15-20 дней.

При лечении отитов препарат используют для.промывания и введения в полость среднего уха по 2-5 мл 1-3 раза в день. Курс лечения 7-15 дней.

При лечении воспалений пазух носа препарат используют для промывания полости носа, носоглотки и пазух носа в дозе 5-10 мл и введения в пазухи 2-3 мл. Процедуру повторяют ежедневно однократно в течение 7-10 дней. Кроме того, препарат вводят в полость носа в виде турунд, смоченных бактериофагом, по очереди и в каждый носовой ход и оставляют в течение 0,5-1 часа. Процедуру повторяют 3 раза в день, курс лечения 7-15 дней.

При лечении стоматитов и хронических пародонтитов препарат используют в виде полосканий полости рта 3-4 раза в день в дозе 10-20 мл, а также введением в пародонтальные карманы турунд, пропитанных бактериофагом клебсиелл, на 5-10 мин, курс лечения 7-10 дней.

При конъюнктивитах и кератоконъюнктивитах препарат применяют по 2-3 капли 4-5 раз в день, курс лечения 5-7 дней; при гнойной язве роговицы - по 4-5 капель в день в течение 7-10 дней; при гнойных иридоциклитах - по 6-8 капель каждые 3 часа в сочетании с приемом внутрь в терапевтических дозировках в течение 7-10 дней.

При абсцессах после вскрытия и удаления гнойного содержимого препарат вводят в количестве меньшем, чем объем удаленного гноя ежедневно однократно, курс лечения 7-10 дней.

При перитонитах и плевритах препарат вводят в дренированные полости - брюшную и плевральную через дренажные трубки ежедневно однократно 20-70 мл, курс лечения 10- 15 дней.

При остеомиелитах препарат вводят в полость раны через турунды, дренажи в количестве 10-30 мл ежедневно однократно, курс лечения 15-20 дней.

При лечении нагноений ран препарат применяют в виде орошения, аппликаций, повязок, введения в дренаж в дозе 5-50 мл в зависимости от очага поражения не менее одного раза в день, курс лечения 10-15 дней.

При лечении гнойно-воспалительных гинекологических заболеваний (нагноений ран, эндометритов, вульвитов, бартолинитов, кольпитов, сальпингоофоритов) препарат используют для орошений, аппликаций, вводят в полости ран, вагины, матки по 5-20 мл один раз в день в течение 7-10 дней.

При циститах, пиелонефритах, уретритах препарат принимают внутрь в терапевтической дозе 3 раза в день за 1 час до еды в течение 10-20 дней. В том случае, если полость мочевого пузыря или почечной лоханки дренированы, препарат вводят через цистостому, или нефростому 1-3 раза в день по 20-50 мл в мочевой пузырь и 5-7 мл в почечную лоханку, курс лечения 7-15 дней.

При гастоэнтероколитах, панкреатитах, холециститах, а также дисбактериозах кишечника бактериофаг принимают внутрь в возрастных дозировках 3 раза в день за 1 час до еды в течение 7-15 дней (по клиническим показаниям). При неукротимой рвоте препарат применяют в виде высоких клизм 2-3 раза в день по 20-40 мл. При дисбактериозе кишечника препарат может применяться с препаратами нормофлоры.

Для профилактики внутрибольничных хирургических инфекций препарат используют для обработки послеоперационных и свежеинфицированных ран в дозе 5-50 мл в зависимости от очага поражения ежедневно однократно в течение 5-7 дней.

","

Не установлены.

","

Гиперчувствительность к компонентам препарата.

","specialInstructions","

Важным условием эффективной фаготерапии является предварительное определение чувствительности возбудителя к бактериофагу.

Влияние на способность управлять транспортными средствами, механизмами

Препарат не влияет на способность управлять транспортом или заниматься другими потенциально опасными видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций.

","

Применение препарата возможно в сочетании с другими лекарственными средствами, в том числе с антибиотиками.

","overdose","

О случаях передозировки не сообщалось.

","actionMechanism","pharmacodynamic","

Препарат вызывает специфический лизис бактерий Klebsiella pneumoniae, Klebsiella ozaenae, Klebsiella rhinoscleromatis.

","pharmacokinetic","

Не изучена.

","pregnancy","

Применение при беременности и в период кормления грудью возможно при наличии инфекций, вызванных фагочувствительными штаммами клебсиелл (по рекомендации врача).

","fertility","precautions","indications","

Лечение и профилактика заболеваний, вызванных бактериями Klebsiella pneumoniae, Klebsiella ozaenae, Klebsiella rhinoscleromatis в составе комплексной терапии: озена, склерома; заболевания ЖКТ (гастроэнтероколит, холецистит, панкреатит, дисбактериоз кишечника); воспалительные заболевания новорожденных и детей раннего возраста (гастроэнтероколит, дисбактериоз кишечника, омфалит, пемфигус, пиодермия, септицемия и септикопиемия различной локализации); хирургические инфекции (нагноения ран, гнойные поражения кожи, ожоги, перитонит, плеврит, мастит, остеомиелит, абсцесс); урогегатальные инфекции (цистит, пиелонефрит, уретрит, эндометрит, вульвит, бартолинит, кольпит, сальпингоофорит); гнойно-воспалительные заболевания уха, горла, носа, пазух носа, ротовой полости, глотки, гортани, бронхов, легких и плевры (отит, ангина, фарингит, ларингит, стоматит, пародонтит, гайморит, фронтит, бронхит, пневмония, плеврит); посттравматический конъюнктивит, кератоконъюнктивит, гнойная язва роговицы и иридоциклит; профилактика внутрибольничных инфекций, вызванных клебсиеллами.

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роговицы","SDE2LjA","VII(H00-H59).H15-H22.H16.0","4",{"_164":183,"_132":184,"_130":185,"_168":183,"_126":186,"_128":170,"_171":187,"_173":181},"H16.2","Keratoconjunctivitis","Кератоконъюнктивит","SDE2LjI","VII(H00-H59).H15-H22.H16.2",{"_164":189,"_132":190,"_130":191,"_168":189,"_126":192,"_128":170,"_171":193,"_173":174},"H20","Iridocyclitis","Иридоциклит","SDIw","VII(H00-H59).H15-H22.H20",{"_164":195,"_132":196,"_130":197,"_168":195,"_126":198,"_128":170,"_171":199,"_173":181},"H60.0","Abscess of external ear","Абсцесс наружного уха","SDYwLjA","VIII(H60-H95).H60-H62.H60.0",{"_164":201,"_132":202,"_130":203,"_168":201,"_126":204,"_128":170,"_171":205,"_173":174},"H66","Suppurative and unspecified otitis media","Гнойный и неуточненный средний отит","SDY2","VIII(H60-H95).H65-H75.H66",{"_164":207,"_132":208,"_130":209,"_168":207,"_126":210,"_128":170,"_171":211,"_173":174},"J01","Acute sinusitis","Острый синусит","SjAx","X(J00-J99).J00-J06.J01",{"_164":213,"_132":214,"_130":215,"_168":213,"_126":216,"_128":170,"_171":217,"_173":174},"J02","Acute pharyngitis","Острый фарингит","SjAy","X(J00-J99).J00-J06.J02",{"_164":219,"_132":220,"_130":221,"_168":219,"_126":222,"_128":170,"_171":223,"_173":174},"J03","Acute tonsillitis","Острый тонзиллит","SjAz","X(J00-J99).J00-J06.J03",{"_164":225,"_132":226,"_130":227,"_168":225,"_126":228,"_128":170,"_171":229,"_173":174},"J04","Acute laryngitis and tracheitis","Острый ларингит и трахеит","SjA0","X(J00-J99).J00-J06.J04",{"_164":231,"_132":232,"_130":233,"_168":231,"_126":234,"_128":170,"_171":235,"_173":174},"J15","Bacterial pneumonia, not elsewhere classified","Бактериальная пневмония, не классифицированная в других рубриках","SjE1","X(J00-J99).J09-J18.J15",{"_164":237,"_132":238,"_130":239,"_168":237,"_126":240,"_128":170,"_171":241,"_173":174},"J20","Acute bronchitis","Острый бронхит","SjIw","X(J00-J99).J20-J22.J20",{"_164":243,"_132":244,"_130":245,"_168":243,"_126":246,"_128":170,"_171":247,"_173":174},"J31","Chronic rhinitis, nasopharyngitis and pharyngitis","Хронический ринит, назофарингит и фарингит","SjMx","X(J00-J99).J30-J39.J31",{"_164":249,"_132":250,"_130":251,"_168":249,"_126":252,"_128":170,"_171":253,"_173":181},"J31.0","Chronic rhinitis","Хронический ринит","SjMxLjA","X(J00-J99).J30-J39.J31.0",{"_164":255,"_132":256,"_130":257,"_168":255,"_126":258,"_128":170,"_171":259,"_173":174},"J32","Chronic sinusitis","Хронический синусит","SjMy","X(J00-J99).J30-J39.J32",{"_164":261,"_132":262,"_130":263,"_168":261,"_126":264,"_128":170,"_171":265,"_173":174},"J36","Peritonsillar abscess","Перитонзиллярный абсцесс","SjM2","X(J00-J99).J30-J39.J36",{"_164":267,"_132":268,"_130":269,"_168":267,"_126":270,"_128":170,"_171":271,"_173":181},"J39.0","Retropharyngeal and parapharyngeal abscess","Ретрофарингеальный и парафарингеальный абсцесс","SjM5LjA","X(J00-J99).J30-J39.J39.0",{"_164":273,"_132":274,"_130":275,"_168":273,"_126":276,"_128":170,"_171":277,"_173":174},"J85","Abscess of lung and mediastinum","Абсцесс легкого и средостения","Sjg1","X(J00-J99).J85-J86.J85",{"_164":279,"_132":280,"_130":281,"_168":279,"_126":282,"_128":170,"_171":283,"_173":174},"J90","Pleural effusion, not elsewhere classified","Плевральный выпот, не классифицированный в других рубриках","Sjkw","X(J00-J99).J90-J94.J90",{"_164":285,"_132":286,"_130":287,"_168":285,"_126":288,"_128":170,"_171":289,"_173":174},"K05","Gingivitis and periodontal diseases","Гингивит и болезни пародонта","SzA1","XI(K00-K93).K00-K14.K05",{"_164":291,"_132":292,"_130":293,"_168":291,"_126":294,"_128":170,"_171":295,"_173":181},"K11.3","Abscess of salivary gland","Абсцесс слюнной железы","SzExLjM","XI(K00-K93).K00-K14.K11.3",{"_164":297,"_132":298,"_130":299,"_168":297,"_126":300,"_128":170,"_171":301,"_173":174},"K12","Stomatitis and related lesions","Стоматит и родственные поражения","SzEy","XI(K00-K93).K00-K14.K12",{"_164":303,"_132":304,"_130":305,"_168":303,"_126":306,"_128":170,"_171":307,"_173":181},"K12.2","Cellulitis and abscess of mouth","Флегмона и абсцесс области рта","SzEyLjI","XI(K00-K93).K00-K14.K12.2",{"_164":309,"_132":310,"_130":311,"_168":309,"_126":312,"_128":170,"_171":313,"_173":181},"K29.7","Gastritis, unspecified","Гастрит неуточненный","SzI5Ljc","XI(K00-K93).K20-K31.K29.7",{"_164":315,"_132":316,"_130":317,"_168":315,"_126":318,"_128":170,"_171":319,"_173":181},"K29.9","Gastroduodenitis, unspecified","Гастродуоденит неуточненный","SzI5Ljk","XI(K00-K93).K20-K31.K29.9",{"_164":321,"_132":322,"_130":323,"_168":321,"_126":324,"_128":170,"_171":325,"_173":181},"K35.2","Acute appendicitis with generalized peritonitis","Острый аппендицит с генерализованным перитонитом","SzM1LjI","XI(K00-K93).K35-K38.K35.2",{"_164":327,"_132":328,"_130":329,"_168":327,"_126":330,"_128":170,"_171":331,"_173":181},"K35.3","Acute appendicitis with localized peritonitis","Острый аппендицит с ограниченным перитонитом","SzM1LjM","XI(K00-K93).K35-K38.K35.3",{"_164":333,"_132":334,"_130":335,"_168":333,"_126":336,"_128":170,"_171":337,"_173":181},"K57.8","Diverticular disease of intestine, part unspecified, with perforation and abscess","Дивертикулярная болезнь кишечника, неуточненной части, с прободением и абсцессом","SzU3Ljg","XI(K00-K93).K55-K64.K57.8",{"_164":339,"_132":340,"_130":341,"_168":339,"_126":342,"_128":170,"_171":343,"_173":181},"K63.0","Abscess of intestine","Абсцесс кишечника","SzYzLjA","XI(K00-K93).K55-K64.K63.0",{"_164":345,"_132":346,"_130":347,"_168":345,"_126":348,"_128":170,"_171":349,"_173":181},"K63.8","Other specified diseases of intestine","Другие уточненные болезни кишечника","SzYzLjg","XI(K00-K93).K55-K64.K63.8",{"_164":351,"_132":352,"_130":353,"_168":351,"_126":354,"_128":170,"_171":355,"_173":174},"K65","Peritonitis","Перитонит","SzY1","XI(K00-K93).K65-K67.K65",{"_164":357,"_132":358,"_130":359,"_168":357,"_126":360,"_128":170,"_171":361,"_173":181},"K75.0","Abscess of liver","Абсцесс печени","Szc1LjA","XI(K00-K93).K70-K77.K75.0",{"_164":363,"_132":364,"_130":365,"_168":363,"_126":366,"_128":170,"_171":367,"_173":181},"K81.9","Cholecystitis, unspecified","Холецистит неуточненный","SzgxLjk","XI(K00-K93).K80-K87.K81.9",{"_164":369,"_132":370,"_130":371,"_168":369,"_126":372,"_128":170,"_171":373,"_173":181},"K86.9","Disease of pancreas, unspecified","Болезнь поджелудочной железы неуточненная","Szg2Ljk","XI(K00-K93).K80-K87.K86.9",{"_164":375,"_132":376,"_130":377,"_168":375,"_126":378,"_128":170,"_171":379,"_173":174},"L02","Cutaneous abscess, furuncle and carbuncle","Абсцесс кожи, фурункул и 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нефрит","TjEx","XIV(N00-N99).N10-N16.N11",{"_164":411,"_132":412,"_130":413,"_168":411,"_126":414,"_128":170,"_171":415,"_173":181},"N15.1","Renal and perinephric abscess","Абсцесс почки и околопочечной клетчатки","TjE1LjE","XIV(N00-N99).N10-N16.N15.1",{"_164":417,"_132":418,"_130":419,"_168":417,"_126":420,"_128":170,"_171":421,"_173":181},"N30.9","Cystitis, unspecified","Цистит неуточненный","TjMwLjk","XIV(N00-N99).N30-N39.N30.9",{"_164":423,"_132":424,"_130":425,"_168":423,"_126":426,"_128":170,"_171":427,"_173":174},"N34","Urethritis and urethral syndrome","Уретрит и уретральный синдром","TjM0","XIV(N00-N99).N30-N39.N34",{"_164":429,"_132":430,"_130":431,"_168":429,"_126":432,"_128":170,"_171":433,"_173":174},"N70","Salpingitis and oophoritis","Сальпингит и оофорит","Tjcw","XIV(N00-N99).N70-N77.N70",{"_164":435,"_132":436,"_130":437,"_168":435,"_126":438,"_128":170,"_171":439,"_173":174},"N71","Inflammatory disease of uterus, except cervix","Воспалительная болезнь матки, кроме шейки матки","Tjcx","XIV(N00-N99).N70-N77.N71",{"_164":441,"_132":442,"_130":443,"_168":441,"_126":444,"_128":170,"_171":445,"_173":174},"N72","Inflammatory disease of cervix uteri","Воспалительная болезнь шейки матки","Tjcy","XIV(N00-N99).N70-N77.N72",{"_164":447,"_132":448,"_130":449,"_168":447,"_126":450,"_128":170,"_171":451,"_173":174},"N75","Diseases of Bartholin gland","Болезни бартолиновой железы","Tjc1","XIV(N00-N99).N70-N77.N75",{"_164":453,"_132":454,"_130":455,"_168":453,"_126":456,"_128":170,"_171":457,"_173":174},"N76","Other inflammation of vagina and vulva","Другие воспалительные болезни влагалища и вульвы","Tjc2","XIV(N00-N99).N70-N77.N76",{"_164":459,"_132":460,"_130":461,"_168":459,"_126":462,"_128":170,"_171":463,"_173":181},"T30","Burn and corrosion, body region unspecified","Термические и химические ожоги неуточненной локализации","VDMw","XIX(S00-T98).T20-T32.T29-T32.T30",{"_164":465,"_132":466,"_130":467,"_168":465,"_126":468,"_128":170,"_171":469,"_173":181},"T79.3","Post-traumatic wound infection, not elsewhere classified","Посттравматическая раневая инфекция, не классифицированная в других рубриках","VDc5LjM","XIX(S00-T98).T79-T79.T79.3",{"_164":471,"_132":472,"_130":473,"_168":471,"_126":474,"_128":170,"_171":475,"_173":174},"O91","Infections of breast associated with childbirth","Инфекции молочной железы, связанные с деторождением","Tzkx","XV(O00-O99).O85-O92.O91",{"_164":477,"_132":478,"_130":479,"_168":477,"_126":480,"_128":170,"_171":481,"_173":174},"P36","Bacterial sepsis of newborn","Бактериальный сепсис новорожденного","UDM2","XVI(P00-P96).P35-P39.P36",{"_164":483,"_132":484,"_130":485,"_168":483,"_126":486,"_128":170,"_171":487,"_173":174},"P38","Omphalitis of newborn with or without mild haemorrhage","Омфалит новорожденного с небольшим кровотечением или без него","UDM4","XVI(P00-P96).P35-P39.P38",{"_164":489,"_132":490,"_130":491,"_168":489,"_126":492,"_128":170,"_171":493,"_173":181},"P39.4","Neonatal skin infection","Неонатальная инфекция кожных покровов","UDM5LjQ","XVI(P00-P96).P35-P39.P39.4",{"_164":495,"_132":496,"_130":497,"_168":495,"_126":498,"_128":170,"_171":499,"_173":174},"P78","Other perinatal digestive system disorders","Другие расстройства системы пищеварения в перинатальном периоде","UDc4","XVI(P00-P96).P75-P78.P78",{"_164":501,"_132":502,"_130":503,"_168":501,"_126":504,"_128":170,"_171":505,"_173":181},"R09.1","Pleurisy","Плеврит","UjA5LjE","XVIII(R00-R99).R00-R09.R09.1",{"_164":507,"_132":508,"_130":509,"_168":507,"_126":510,"_128":170,"_171":511,"_173":181},"Z29.8","Other specified prophylactic measures","Другие уточненные профилактические меры","WjI5Ljg","XXI(Z00-Z99).Z20-Z29.Z29.8","atc",[514],{"_164":515,"_132":516,"_130":517,"_126":518,"_128":519,"_171":518,"_173":174},"V.03.A","All Other Therapeutic 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Бактериофаг клебсиелл поливалентный очищенный (Bakteriofag klebsiyell polivalentnyy ochishchennyy)